New Study Shows Age-Related Decline in Stemness Across Human Tissues
A recent study published in Aging journal sheds light on the impact of aging on stem cells in human tissues. A team of researchers from Universidade de Sao Paulo, University of Birmingham, and the University of Liverpool utilized machine learning to analyze transcriptome data from healthy human tissues.
The study, titled Evidence of a pan-tissue decline in stemness during human aging, examined samples from individuals aged 20 to 79 across 30 different human tissues. The researchers discovered that approximately 60% of the tissues exhibited a significant decrease in stemness scores with age. However, the uterus showed a unique increase in stemness as individuals grew older.
Moreover, the study revealed that stemness is closely linked to cell proliferation and inversely related to cellular senescence. Interestingly, there was a suggestion that hematopoietic stem cells from older individuals may have higher stemness scores.
Overall, the findings point towards a widespread decline in stemness across human tissues as individuals age. This decline in stem cell function could potentially play a role in the aging process, highlighting the importance of further research in this area.
