Benefits of Broccoli Consumption: Lower Risk of Diseases and Protection of Gut Lining

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The recent research conducted by researchers from Penn State University has revealed that broccoli is more than just a superfood. It turns out broccoli is packed with natural chemicals capable of binding to a receptor in mice that ultimately helps protect the lining of the small intestine from harm. The study was published in the journal Laboratory Investigation.

The head researcher, Gary Perdew, H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences, Penn State revealed that besides just being healthy, we need to know what activities occur in our bodies when we consume broccoli amongst other vegetables. The research revealed that increased intake of cruciferous vegetables helps to reduce the risks of type 2 diabetes and cancer.

The group of researchers analysed the mice diet containing 15% broccoli and compared it to a control group of mice with no broccoli diet. Post the experimentation, it was observed that the mice fed with broccoli had significantly more AHR activity.

AHR is a type of protein – a transcription factor. This binding then initiated a variety activities that contribute to the functionality of small intestine cells. According to the study, the wall of the small intestine is only as effective in protecting the body from germs and bacteria as the cells that line the small intestine such as enterocytes, goblet cells and Paneth cells.

The results demonstrated that mice which were not fed broccoli lacked AHR activity and thus, the small intestine did not have enough function to permit water and other necessary nutrients to pass effectively. Additionally, the number of goblet cells and protective mucus in the intestinal wall were found to be reduced and a decrease in Paneth cells and lysosome production was also noted.

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It is concluded from the study that a diet rich in broccoli, cabbage and Brussels sprouts help to ensure resilience in the small intestine which further leads to a healthy body. Andrew Patterson, John T. and Paige S. Smith Professor of Molecular Toxicology and of Biochemistry and Molecular Biology also noted that dietary cues received through AHR helps to shape the metabolic capacities of the gastrointestinal tract.

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The researcher mentioned in the original article is Gary Perdew. He is the H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences at Penn State. He made a profound contribution to the research. He believes that broccoli is not only healthy but people need to know what happened in their bodies when they consume broccoli. He has made it his mission to uncover the mechanisms of how broccoli and other food benefit health in humans and mice.

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